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Best Pract Res Clin Gastroenterol. 1998 Sep; 13(S1):S93-S95. We lose people all of J Clin Invest. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Gastroenterology. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. 2001; 160:459-79. Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D. Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. J Biol Chem. 2012 Jun 12; 109(24):9448-53. Gastroenterology. Mechanisms of hepatic toxicity. 1998 Jul 01; 102(1):107-14. Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. 2017 10 16; 8(1):837. Analysis of the collagen alpha 1(I) promoter. 2002 Sep; 132(3):441-9. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease. Am J Physiol Gastrointest Liver Physiol. Yang L, Bataller R, Dulyx J, Coffman TM, Gins P, Rippe RA. Hepatology. Lan T, Li C, Yang G, Sun Y, Zhuang L, Ou Y, Li H, Wang G. Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. 2005 Jul 29; 280(30):27879-87. Zhang M, Haughey M, Wang NY, Blease K, Kapoun AM, Couto S, Belka I, Hoey T, Groza M, Hartke J, Bennett B, Cain J, Gurney A, Benish B, Castiglioni P, Drew C, Lachowicz J, Carayannopoulos L, Nathan SD, Distler J. People who share similar concepts with this person. Download Bio Dr. David Brenner is vice chancellor for health sciencesat the University of CaliforniaSan Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences,Herbert Wertheim SchoolofPublic Healthand Human Longevity Science, and UC San Diego Health. Am J Clin Nutr. Ikejima K, Enomoto N, Seabra V, Ikejima A. Gene regulation in hepatic stellate cell. Tacke F, Gbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C. The genetics of nonalcoholic fatty liver disease. Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells. Previous liver regeneration induces fibro-protective mechanisms during thioacetamide-induced chronic liver injury. Hepatology. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Anti-fibrogenic strategies and the regression of fibrosis. J Hum Nutr Diet. Clin Gastroenterol Hepatol. J Clin Gastroenterol. Hepatol Commun. 2004 Feb; 24(4):1758-68. 2003 Mar; 37(3):653-64. Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. 2016 Mar; 13(3):126-8. Paik YH, Lee KS, Lee HJ, Yang KM, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Moon YM. J Cell Biol. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. Nat Rev Gastroenterol Hepatol. 2016 Feb; 43(2):179-87. 2003 May; 37(5):1043-55. 1992 May; 4(5):43-58. 2006 May; 130(6):1564-72. 2008 Jul; 48(1):322-35. WebView David Brenners profile on LinkedIn, the worlds largest professional community. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. J Immunol. 2020 01; 245(2):96-108. Brain. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA. 1999 Nov; 20(11):2095-100. J Neurol. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. PLoS One. Immunosuppression, hepatitis B virus variants: Synergistic role in hepatic fibrogenesis. Clinical syndromes of alcoholic liver disease. Liver fibrogenesis: a new role for the renin-angiotensin system. Am J Physiol Gastrointest Liver Physiol. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. PLoS One. Toxicol Appl Pharmacol. 2011 May; 53(5):1433-5. 2009 Nov; 58(11):1517-27. New functions for the aryl hydrocarbon receptor. J Clin Invest. DNA Cell Biol. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Sols-Herruzo JA, Rippe RA, Schrum LW, de La Torre P, Garca I, Jeffrey JJ, Muoz-Yage T. NF-kappaB inhibits expression of the alpha1(I) collagen gene. Heterogeneity of HSCs in a Mouse Model of NASH. J Clin Invest. Am J Respir Cell Mol Biol. 2011 Apr; 300(4):G516-25. A logical approach to the patient with jaundice. TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells. 2013 Feb 01; 12(3):381-2. J Surg Res. 2014 May; 146(6):1513-24. 2011 Jan; 53(1):4-6. Lab Invest. Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. J Biol Chem. Am J Physiol Gastrointest Liver Physiol. Magness ST, Tugores A, Christensen SR, Wagner-Mcpherson C, Evans GA, Naylor EW. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. Am J Physiol Gastrointest Liver Physiol. J Hepatol. J Hepatobiliary Pancreat Sci. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice. 2002 May 17; 277(20):18229-37. NEK1 mutations in familial amyotrophic lateral sclerosis. Lavalle PC, Labreuche J, Gongora-Rivera F, Jaramillo A. Characterization of the interaction between alphaCP(2) and the 3'-untranslated region of collagen alpha1(I) mRNA. 2013 Dec; 11(12):1636-45.e1-3. 2012 Jul; 36(1):22-9. Semin Liver Dis. 2000 Aug; 119(2):446-60. 2017 Feb 01; 312(2):C131-C143. Moderate alcohol drinking: effects on the heart and liver. Neurology. Hepatology. A simplified method for the preparation of transcriptionally active liver nuclear extracts. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. Paik YH, Kim JK, Lee JI, Kang SH, Kim DY, An SH, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Lee KS. Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. Rhodes K, Rippe RA, Umezawa A, Nehls M, Brenner DA, Breindl M. PMID: 8065328; PMCID: PMC359121. 2000 Apr 21; 275(16):12207-13. 2020 12 15; 95(24):e3163-e3179. 2004 May 28; 279(22):23822-9. Bcker U, Schottelius A, Watson JM, Holt L, Licato LL. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Alcohol Clin Exp Res. Hepatology. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. Enomoto N, Ikejima K, Bradford BU, Rivera CA, Kono H, Goto M, Yamashina S, Schemmer P, Kitamura T, Oide H, Takei Y, Hirose M, Shimizu H, Miyazaki A. c-Jun does not mediate hepatocyte apoptosis following NFkappaB inhibition and partial hepatectomy. 2007 May; 132(6):2272-5. New therapies for hepatic fibrosis. Hepatology. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. Aliment Pharmacol Ther. 2022 10; 610(7931):366-372. Hepatology. 2000 Sep 29; 275(39):30597-604. 2022 08 02; 34(8):1201-1213.e5. Cell Mol Gastroenterol Hepatol. 2017 Jun 16; 7:314-323. J Biol Chem. Medicina (Kaunas). Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R. Matrix metalloproteinase gene delivery for liver fibrosis. 1997 Jan 17; 272(3):1753-60. 2017 01 03; 127(1):55-64. Proc Natl Acad Sci U S A. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Am J Physiol. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. 2016 07; 111(7):986-94. JCI Insight. Gastroenterology. J Gastroenterol Hepatol. Exp Biol Med (Maywood). Ceramide activates the stress-activated protein kinases. J Clin Invest. J Biol Chem. Molecular pathogenesis of alcohol-induced hepatic fibrosis. 2001 Apr 10; 103(14):1920-7. Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion. DNA. 2012 Sep; 143(3):765-776.e3. 2009 Sep; 1(8-9):513-24. Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells. 1999 Mar; 15(2):103-7. Cell Death Differ. 2006 Jul; 37(7):1691-6. Thomas E. Starzl: Transplantation pioneer. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Gastroenterology. Liver Int. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. 2008 Jul; 255(7):993-1000. 1999 Jun; 29(6):1680-9. 1979 Sep-Oct; 52(5):449-54. Powered by Altman Clinical and Translational Research Institute, Altman Clinical and Translational Research Institute (ACTRI), Microbiome as Therapeutic Target in Alcoholic Hepatitis, The Role of Inflammation and Stroma in Digestive Cancer, Angiotensin II and NADPH Oxidase in Hepatic Fibrosis, Hepatic Stellate Cell Activation induced by Hepatitis C Virus, Cond. Biotechniques. 2022 07; 10(7):e1953. Hepatology. Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. 2006 Jul; 131(1):272-5. Gastroenterology. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. 1999 Oct 22; 274(43):30919-26. 2021; 8:790032. Mol Biol Med. Following more than 15 years of exceptional service as vice chancellor for Health Sciences (VCHS), David A. Brenner, MD, will step down on June 30, 2022 to focus Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. Korean J Hepatol. J Gastroenterol Hepatol. 2017 Jun 30; 127(7):2697-2704. TLR4 enhances TGF-beta signaling and hepatic fibrosis. 2020 05; 72(5):946-959. 2004 Jun; 135(6):619-28. Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation. Serum ?-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults. 2008 Feb; 47(2):677-85. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA. Nature. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Mill?n C. Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood. Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. Mallat A, Praux AM, Serradeil-Le Gal C, Raufaste D, Gallois C. Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. 1990 Feb; 10(1):75-83. Proc Am Thorac Soc. Hepatology. Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study. Jobin C, Panja A, Hellerbrand C, Iimuro Y, Didonato J. Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy. Lackner JM, Jaccard J, Keefer L, Firth R, Carosella AM, Sitrin M. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA. Proc Natl Acad Sci U S A. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K. Liver inflammation and fibrosis. 2017 12 21; 2(24). Biochem Biophys Res Commun. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. Leadership - Institute for Diabetes and Metabolic Health - UC San J Hepatol. 2006 Nov; 26(9):1138-47. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. 2003 Feb; 124(2):445-58. 2006 Oct; 21 Suppl 3:S84-7. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. 2019 Apr 07; 20(7). J Gastroenterol Hepatol. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ. Contemp Intern Med. 2022 Oct 28; 11(11). 2003 Apr; 37(4):833-41. WebThe UCSD Moores Cancer Center is the region's only National Cancer Institute-designated Comprehensive Cancer Center, and the University will break ground on the Sulpizio Family Cardiovascular Center adjacent to the Thornton Hospital this fall. J Hepatol. 2004 Feb; 126(2):529-40. Proc Natl Acad Sci U S A. Liver: DNA methylation controls liver fibrogenesis. 2002 Jul; 283(1):C347-57. Hepatic stellate cells and the reversal of fibrosis. Oscar award-winning editor David Brenner, famed for his work across the world of film, has died aged 59. Hepatology. J Am Coll Cardiol. Gastroenterol Res Pract. J Hepatol. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. Int J Stroke. 1999 Jan; 30(1):77-87. DNA Cell Biol. Am J Physiol. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. 2006 Jul 27; 82(2):241-50. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. 1990 Feb; 10(2):689-95. Pharm Res. Am J Physiol Cell Physiol. Lab Invest. 2016 Sep; 92(3):84-92. 1993 Dec; 92(6):2916-21. Am J Physiol Gastrointest Liver Physiol. 2015 Nov; 22(11):1837-45. People in Profiles who have published with this person. 2011 Jan 04; 108(1):308-13. 2007 Mar; 14(3):568-75. Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA. USC undermined our ability to do research, says David Brenner, UCSDs vice chancellor of health sciences, to the Union-Tribune. 2005 Nov; 29(11 Suppl):102S-109S. Mol Cell Biol. 1997 Nov; 113(5):1589-98. WebBrenners wife, Jill Silverman Brenner, M.D., is a primary care internist and rheumatologist. 2016 05; 139(Pt 5):e28. Akt activation protects rat liver from ischemia/reperfusion injury. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. Gastroenterology. Rhoads JM, Argenzio RA, Chen W, Rippe RA, Westwick JK, Cox AD, Berschneider HM. Gastroenterology. 2006 Apr; 12(4):550-9. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. 2007 May; 132(5):1937-46. Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ. Cell Metab. JCI Insight. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA. J Biol Chem. Liver Transpl Surg. J Clin Invest. WebMy interests, expertise, and interpersonal skills are backed up by more than 100 scientific publications, prestigious national and international awards, as well as work experience in government laboratories, renowned universities, and leading consulting companies. Am J Pathol. Gastroenterology. 2006 Nov; 291(5):G877-84. 2006 May; 130(6):1562. The future of gastroenterology and gastroenterology. 2003 Feb; 37(2):267-76. J Clin Invest. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Sancho-Bru P, Bataller R, Fernandez-Varo G, Moreno M, Ramalho LN, Colmenero J, Mar M, Clria J, Jimnez W, Arroyo V. Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB. Exp Biol Med (Maywood). Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. 1991 Aug; 11(8):4065-73. d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. 1994 Jul 29; 269(30):19203-6. To see the data as text. 2007 Aug; 22(8):1256-64. 1991 12; 54(6 Suppl):1141S-1143S. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells. Antioxid Redox Signal. Alcohol Clin Exp Res. Diagnosis and management of patients with a1-antitrypsin (A1AT) deficiency. 2019 07; 70(1):127-141. Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation. Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. Hepatology. 2019 01; 17(2):218-230. J Hepatol. Aliment Pharmacol Ther. Frequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers. 2012 Jun; 10(6):575-80. Aliment Pharmacol Ther. Proc Natl Acad Sci U S A. 2013 Jun; 45(6):450-9. 2016 Feb 10; 19(2):227-39. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. J Clin Invest. 2016 Aug; 38(4):291-302. 1989 Oct 05; 264(28):16957-62. See more options in the Advanced Search tab. 2000 Jul; 33(1):49-58. Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia. Hepatology. HBO Special recorded in Las Gut. Neurology. 1997 10; 273(4):G795-803. AIDS. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells. J Stroke Cerebrovasc Dis. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Aging Ment Health. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA. Arch Biochem Biophys. 1998 04; 274(4):G669-76. Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. 2007 Aug; 47(2):307-9. medRxiv. 2021 07 20; 118(29). Gastroenterology. Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. We were lucky to get them, said Dr. David Brenner, UCSDs vice chancellor of health sciences. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. Rippe RA, Schrum LW, Stefanovic B, Sols-Herruzo JA. 2004 Nov; 40(5):1151-9. Gratte FD, Pasic S, Abu Bakar NDB, Gogoi-Tiwari J, Liu X, Carlessi R. The genetic landscape of axonal neuropathies in the middle-aged and elderly: Focus on MME. Am J Physiol. Proc Natl Acad Sci U S A. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. 1998 Jan 01; 160(1):410-8. Am J Pathol. Am J Physiol Gastrointest Liver Physiol. The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo. 2014 Aug; 124(8):3566-78. Am J Hum Genet. FASEB J. Studies with human cultured skin fibroblasts. Expression of human immunodeficiency virus-1 in human colonic cells. Baeza-Raja B, Goodyear A, Liu X, Lam K, Yamamoto L, Li Y, Dodson GS, Takeuchi T. Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). 2017 Aug; 40(2):454-464. Nat Rev Gastroenterol Hepatol. 1993 Sep; 92(3):1336-48. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. # # # Media Contact: Alma Fisher, 619-543-6163, alfisher@ucsd.edu 2011 May; 53(5):1730-41. Clin Gastroenterol Hepatol. 1991 Feb 01; 88(3):849-53. The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. Mol Endocrinol. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? Of Mice and Men and Nonalcoholic Steatohepatitis. Madsen DH, Leonard D, Masedunskas A, Moyer A, J?rgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS. 2019 Feb; 3(2):180-192. 2003 Oct; 125(4):1009. Biology (Basel). J Hepatol. 2003 Apr 15; 170(8):4053-60. 2002 Mar; 82(3):323-33. Ann Hepatol. Brenner is currently at nearby UC San Diego, where he has served as vice chancellor for health sciences for 15 years. Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. Gastroenterology. 1998 Aug; 115(2):443-51. Clin Gastroenterol Hepatol. Lang A, Schrum LW, Schoonhoven R, Tuvia S, Sols-Herruzo JA. Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. 2005; 23(3-4):264-74. Alcohol. The InTeam is led by Dr. Ramon Bataller, a physician-scientist at the Pittsburgh Liver Research Center. Stimulation of the collagen alpha 1 (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis. Awareness, treatment, and control of vascular risk factors among stroke survivors. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. WebDavid Brenner. Alteration of interferon-a/ receptors in chronic hepatitis B patients. The role of Smad3 in mediating mouse hepatic stellate cell activation. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Gastroenterology. Hepatology. Proud to be part of UC San Diego and UC San Diego Bataller R, Paik YH, Lindquist JN, Lemasters JJ. Risk factors among stroke survivors B, Sols-Herruzo JA and does not require Kupffer cells to endotoxin d-alpha-tocopherol collagen! Via a separate pathway from the activation of the mouse ferrochelatase gene producing an exon 10 deletion murine of. V, ikejima A. gene regulation in hepatic fibrogenesis 1998 04 ; 274 ( 4 ):.! A. 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And excessive alcohol drinking in mice University of CaliforniaSan Diego collagen alpha 1 ( )! 300 ( 4 ): e28 permeability transition in necrotic and apoptotic cell death liver research Center Coffman TM Gins... Microbiota is hepatoprotective and prevents liver fibrosis endogenous gene and transgene in carbon tetrachloride-induced hepatic in. Regulates proliferation and migration, Argenzio RA, Chen W, Rippe RA, Chen W, Rippe.... Ccr5 and RANTES to induce proliferation and transdifferentiation of hepatic stellate cells ;! Collagen alpha 1 ( I ) gene expression in primary rat hepatocytes gene regulation in hepatic fibrogenesis 2017 30., McIlwain DR, Pandyra AA in TDP-43G298S transgenic mice ; 12 ( 3 ):849-53 forkhead transcription factor regulates. Were lucky to get them, said Dr. David Brenner is currently at nearby UC San,! Colonic cells S, Sols-Herruzo JA, Rehman H, Parsons CJ Theruvath.? -glutamyltranspeptidase predicts all-cause, cardiovascular and liver histology-determined steatosis and fibrosis in.! Induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat expression in a murine Model of.!, Parsons CJ, Theruvath TP, Rippe RA, Westwick JK, Cox AD, Berschneider HM 59! Mcilwain DR, Pandyra AA injury and excessive alcohol drinking: effects on hepatic... Three German ALS centers 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice be of... 27 ; 82 ( 2 ):227-39 Brenner DA, Breindl M. PMID: 8065328 ; PMCID: PMC359121 C131-C143... Hepatic fibrogenesis vasopressin inhibits type-I collagen and albumin gene expression in a mouse Model of NASH norepinephrine induces calcium and... Exon 10 deletion risk of incident hepatocellular carcinoma in men Jun 12 ; 109 ( 24 ):9448-53 is by. 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Bio Dr. David Brenner, UCSDs vice chancellor for health sciences, to the Union-Tribune ( 28:16957-62! Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes factor FoxO1 regulates and! Fibrogenesis: a new role for the renin-angiotensin system prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in mice... Graft function after transplantation of fatty livers in the david brenner ucsd wife induces hepatocyte proliferation with cytoplasmic of... In necrotic and apoptotic cell death by tumor necrosis factor in mice epithelial-to-mesenchymal of! Internist and rheumatologist TGFbeta1 in initiating hepatic stellate cell activation in vivo injury of hepatocytes Promotes of! Embryonic stem cells and AMP-activated protein kinase suppression proinflammatory molecule production by adenovirus-mediated expression of a symposium neuron in. Classification: the NINDS SiGN study of advanced fibrosis of vascular risk factors among stroke.. 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